This highly sensitive ChIP-seq, kit only requires standard laboratory equipment and will target researcher and clinicians working with small volume samples. The inventors of the method plan to publish it in a high profile paper within summer 2018.
Inven2 AS seeks a licensee of the technology.
The biggest challenge when scaling down ChIP-seq from millions of cells to only a few samples is to be able to still distinguish the signal from the background noise. The uniqueness of this method is the ability to efficiently compete out the noise introduced by unspecific binding. The method is thoroughly validated. Recently they succeeded with over 1 million reads per single cell which is out-standing results, and a huge improvement compared to the most recent publishing of ChiP-seq in Nature Biotech 2015 (Rotem et.al).
A PCT-application was filed in August 2017